Best Practices for Microsoft 365

Ensure that you factor in data increase forecast while creating the deduplication storage device.

Exclude the deduplication storage location from all anti-virus scanners including Microsoft Defender.

Set the deduplication storage concurrent operations according to requirements mentioned for Microsoft 365.

Create a deduplication storage device on Solid-state Drives (SSD) or equivalent storage for enhanced performance.

Run only one backup job at a time to avoid overlap.

If the Backup Exec server is a virtual machine, ensure that:

Ensure that the drive in which Backup Exec is installed is different from the drive in which Backup Exec catalog is installed. If your Microsoft 365 jobs are backing up large amounts of data, ensure that the catalog drive has proportionate amount of space.